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Volumetric capnography slopes in ventilated term and preterm infants
Theodore Dassios1, Paul Dixon, Emma Williams
1Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, London, United Kingdom.
Physiological Measurement
|April 17, 2020
Summary
Volumetric capnography slopes did not differ between preterm and term infants. However, the phase III slope correlated with ventilation duration and oxygen needs, suggesting its use in assessing disease severity in newborns.
Area of Science:
- Neonatalogy
- Respiratory Physiology
Background:
- Mechanical ventilation is crucial for preterm and term neonates.
- Volumetric capnography (VCAP) provides insights into respiratory mechanics.
- Understanding VCAP parameters in different neonatal populations is essential.
Purpose of the Study:
- To compare VCAP slopes (Phase II and III) between ventilated preterm and term infants.
- To investigate the relationship between VCAP slopes, gestational age, and ventilation duration.
Main Methods:
- Volumetric capnography was used to measure Phase II (SII) and Phase III (SIII) slopes.
- Measurements were taken in ventilated preterm and term infants.
- Slopes were correlated with gestational age, ventilation duration, and fraction of inspired oxygen (FIO2).
Main Results:
- No significant differences were found in SII or SIII between preterm and term infants.
- SII showed no significant correlation with gestational age, ventilation duration, or FIO2.
- SIII demonstrated a positive correlation with ventilation duration and FIO2.
Conclusions:
- VCAP phase II and III slopes do not significantly differ between preterm and term ventilated neonates.
- The SIII slope's correlation with ventilation duration and FIO2 suggests its potential as an index for disease severity in ventilated newborns.
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