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Normobaric intermittent hypoxic training regulates microglia phenotype and enhances phagocytic activity
Genell Tantingco1, Myoung-Gwi Ryou1,2
1Department of Medical Laboratory Science and Public Health Tarleton State University, Fort Worth, TX 76104, USA.
Experimental Biology and Medicine (Maywood, N.J.)
|April 18, 2020
Summary
Intermittent hypoxic training (IHT) may benefit ischemic stroke recovery by modulating microglia polarization. This research investigates IHT
Area of Science:
- Neuroscience
- Cell Biology
- Physiology
Background:
- Intermittent hypoxic training (IHT) shows promise for various pathological conditions, including ischemic stroke.
- Microglia play a critical dual role in ischemic stroke: beneficial in the acute phase but detrimental during long-term recovery.
- The impact of IHT on microglia polarization remains unexplored.
Purpose of the Study:
- To investigate whether IHT influences microglia polarization.
- To determine if IHT preserves the essential phagocytic function of microglia.
- To elucidate the potential of IHT in improving long-term recovery from ischemic stroke.
Main Methods:
- The study design involves applying intermittent hypoxic training (IHT) protocols.
- Experimental models of ischemic stroke will be utilized.
- Microglia polarization and phagocytic activity will be assessed.
Main Results:
- Results are pending and will be reported upon study completion.
- The study aims to provide novel insights into IHT's effects on microglia.
Conclusions:
- This research is expected to offer pivotal information on IHT's role in modulating microglia during ischemic stroke recovery.
- Findings could inform therapeutic strategies for enhancing long-term outcomes after stroke.
