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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Developing Phytocompounds from Medicinal Plants as Immunomodulators.

Chih-Chun Wen1, Hui-Ming Chen1,2, Ning-Sun Yang1

  • 1Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.

Advances in Botanical Research
|April 18, 2020
PubMed
Summary
This summary is machine-generated.

Medicinal herbs and their phytochemicals show potential as immunomodulators for chronic immune diseases. This review explores their bioactivities and future therapeutic development for immune system regulation.

Keywords:
Anti-cancerImmune-related disordersImmunomodulatory activitiesOrganosulphurTerpernoids

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Area of Science:

  • Immunology and Pharmacology
  • Natural Product Chemistry
  • Drug Discovery and Development

Background:

  • Immune system dysregulation is implicated in chronic diseases like autoimmune disorders, allergies, and cancer.
  • Phytochemicals, derived from medicinal plants, offer a source for therapeutic agents, though their immunomodulatory applications are underexplored.
  • Existing immunotherapies often target specific immune cells within the complex immune network.

Purpose of the Study:

  • To review the immunomodulatory bioactivities of selected medicinal herbs, phytoextracts, and isolated phytochemicals.
  • To assess the potential of these plant-derived compounds as future immunomodulatory and inflammation-regulatory therapeutics.
  • To discuss novel experimental approaches for evaluating phytomedicines' immunomodulatory effects.

Main Methods:

  • Literature review of scientific studies on medicinal herbs and their phytochemicals.
  • Analysis of reported immunomodulatory bioactivities of crude extracts, fractionated phytoextracts, and specific phytocompounds.
  • Categorization of phytocompounds based on chemical structures and their associated immune-modulating effects.

Main Results:

  • A range of medicinal herbs and their derived phytochemicals exhibit significant immunomodulatory properties.
  • Specific chemical structures of phytocompounds correlate with distinct immunomodulatory or inflammation-regulatory activities.
  • The potential for developing these natural compounds into novel immunotherapeutics is highlighted.

Conclusions:

  • Medicinal plants and their constituents represent a promising, yet relatively untapped, resource for developing immunomodulatory agents.
  • Further research and novel experimental strategies are crucial for validating and translating these findings into clinical applications.
  • Phytochemicals hold potential for treating a variety of immune-related diseases by modulating immune system function.