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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Mitogens and the Cell Cycle02:38

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Updated: Dec 23, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
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NCAPG Is a Promising Therapeutic Target Across Different Tumor Types.

Cuicui Xiao1, Jiao Gong2, Yusheng Jie3

  • 1Cell-Gene Therapy Translational Medicine Research Center, Key Laboratory of Liver Disease of Guangdong Province, Guangzhou, China.

Frontiers in Pharmacology
|April 18, 2020
PubMed
Summary
This summary is machine-generated.

Aberrantly expressed NCAPG is linked to poor survival in multiple cancers. This gene may drive tumor growth via cell cycle and DNA repair pathways, offering a potential therapeutic target.

Keywords:
RNA sequencingThe Cancer Genome Atlas; Non-SMC condensin I complex subunit Gbioinformatic analysishepatocellular carcinoma weighted gene co-expression network analysispan-cancer analysis

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Area of Science:

  • Genomics
  • Cancer Biology
  • Molecular Therapeutics

Background:

  • CRISPR-Cas9 technology enables gene therapy, necessitating identification of key cancer-driving genes.
  • Aberrant gene expression is crucial in understanding and treating diverse cancer types.
  • Targeted gene therapies offer potential benefits to a large patient population.

Purpose of the Study:

  • Identify aberrantly expressed genes across various cancer types.
  • Analyze the functional mechanisms and survival correlations of these genes.
  • Evaluate potential molecular targets for cancer therapy.

Main Methods:

  • Comprehensive RNA-Seq analysis of The Cancer Genome Atlas (TCGA) database.
  • Protein-level expression analysis across 16 tumor types.
  • Weighted Gene Co-expression Network Analysis (WGCNA) for hub gene identification.

Main Results:

  • NCAPG was highly expressed in 16 cancer types compared to normal tissues.
  • High NCAPG expression correlated with unfavorable survival in hepatocellular carcinoma (HCC), breast, lung, and ovarian cancers.
  • NCAPG is a hub gene in HCC, associated with cell cycle, senescence, and mismatch repair pathways.

Conclusions:

  • NCAPG is a promising molecular target for cancer therapy.
  • NCAPG overexpression contributes to carcinogenesis and tumor progression.
  • Understanding NCAPG's role in tumor pathways can lead to novel targeted treatments.