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Updated: Dec 23, 2025

Enhancing Tumor Content through Tumor Macrodissection
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Infiltrative Rash Secondary to Leukemic-Phase Diffuse Large B-Cell Lymphoma With t(14;18), CDKN2A and MLL Deletion.

Iris Y Sheng1, Diana O Treaba2, Kenneth D Bishop3

  • 1Department of Internal Medicine, Rhode Island Hospital and Warren Alpert Medical School, 593 Eddy Street, Providence, RI 02903, USA.

Journal of Hematology
|April 18, 2020
PubMed
Summary

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Leukemic-phase Diffuse Large B-cell Lymphoma (DLBCL) is rare. This case presents a unique cutaneous eruption, highlighting the need for tailored chemotherapy regimens like DA-R-EPOCH for MLL- and CDKN2A-positive DLBCL.

Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Diffuse Large B-cell Lymphoma (DLBCL) is an aggressive non-Hodgkin's lymphoma.
  • Leukemic-phase DLBCL is a rare presentation, with limited documented cases.
  • Standard chemotherapy regimens like R-CHOP may be less effective in specific genetic subtypes.

Observation:

  • A rare case of leukemic-phase DLBCL presented with a unique cutaneous eruption on the lower extremities.
  • This specific presentation has not been previously reported in medical literature.
  • The patient's DLBCL was characterized by MLL- and CDKN2A mutations.

Findings:

  • Patients with MLL- and CDKN2A-positive DLBCL may respond better to dose-adjusted EPOCH (DA-R-EPOCH) chemotherapy.
  • DA-R-EPOCH offers a potential alternative to R-CHOP for selected DLBCL patients.
Keywords:
Leukemic-phase DLBCLMLL/CDKNA deletion

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  • This case underscores the heterogeneity of DLBCL presentation and treatment response.

    • Implications:

    • Highlights the importance of considering novel therapeutic strategies for rare DLBCL presentations.
    • Suggests that genetic profiling (MLL, CDKN2A) is crucial for optimizing DLBCL treatment selection.
    • Emphasizes the need for further research into the efficacy of DA-R-EPOCH in specific DLBCL subtypes.