Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

8.9K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
8.9K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.0K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.0K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

404
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
404
Antibody Actions01:26

Antibody Actions

2.2K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
2.2K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

734
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
734
Transcytosis of IgG01:15

Transcytosis of IgG

3.9K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fractional Excretion of Total Protein and Long-Term Kidney Outcomes in Patients With Biopsy-Proven Diabetic Nephropathy: The N-BDN Study.

Diabetes, obesity & metabolism·2026
Same author

Response to Third-Line Erlotinib in Peritoneal Carcinomatosis from Initially EGFR Mutation-Negative Lung Adenocarcinoma, Followed by the Retrospective Confirmation of EGFR Mutation-Positivity by Immunohistochemistry.

Internal medicine (Tokyo, Japan)·2026
Same author

Preventive Effect of Mineralocorticoid Receptor Antagonists Against Proteinuria Induced by Atezolizumab Plus Bevacizumab Therapy in Hepatocellular Carcinoma: A Multicenter Retrospective Study.

Hepatology research : the official journal of the Japan Society of Hepatology·2026
Same author

Liver Paradoxical Reaction Presenting as a Solitary Hepatic Mass During Antituberculosis Therapy: A Case Report.

Internal medicine (Tokyo, Japan)·2026
Same author

SGLT2 inhibitors preserve serum chloride in non-diabetic CKD: a propensity-matched and LASSO regression analysis.

Renal failure·2026
Same author

A Case of IgG4-Related Disease Developing During Long-Term High-Dose Intravenous Epoprostenol Therapy in a Patient With Idiopathic Pulmonary Arterial Hypertension.

Pulmonary circulation·2026

Related Experiment Video

Updated: Dec 23, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.4K

Complement activation is associated with crescent formation in IgA nephropathy.

Hiroe Itami1, Shigeo Hara2, Kenichi Samejima3

  • 1Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, Japan. hritami1237@yahoo.co.jp.

Virchows Archiv : an International Journal of Pathology
|April 18, 2020
PubMed
Summary

IgA nephropathy (IgAN) with C3 complement deposits indicates complement pathway activation. This suggests potential therapeutic targets for improving IgAN prognosis.

Keywords:
ComplementCrescentsIgA nephropathyLight chain

More Related Videos

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

2.2K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.0K

Related Experiment Videos

Last Updated: Dec 23, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.4K
Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

2.2K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.0K

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • IgA nephropathy (IgAN) is a common chronic glomerulonephritis with a variable prognosis.
  • Crescent formation in IgAN is linked to poor renal outcomes.
  • Complement activation, particularly involving C3, is implicated in IgAN pathogenesis.

Purpose of the Study:

  • To investigate the association between C3 deposition and clinical, histological, and immunofluorescence findings in IgAN patients.
  • To explore the role of complement activation pathways in IgAN with crescent formation.

Main Methods:

  • Retrospective analysis of 132 IgAN patients diagnosed via renal biopsy.
  • Classification of patients into groups based on C3 immunofluorescence staining (C≥1 vs. C0).
  • Comparison of clinical, light microscopic (including Oxford classification), and immunofluorescence data (IgA, C5b-9, MASP, properdin, factor B, kappa).

Main Results:

  • Patients with C3 deposits (C≥1 group) were younger, had lower hypertension rates, and higher urinary abnormalities.
  • The C≥1 group showed significantly higher immunofluorescence scores for IgA, C5b-9, MASP-1/3, MASP2, properdin, factor B, and kappa.
  • Steroid use was higher in the C≥1 group, and renal dysfunction rates were similar between groups during follow-up.

Conclusions:

  • Crescent formation in IgAN is associated with the activation of lectin and alternative complement pathways.
  • C3 deposition in IgAN patients correlates with specific immunofluorescence findings and increased steroid treatment.
  • Further research into complement-targeted therapies may be beneficial for IgAN management.