Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Cancer Vaccines01:30

Cancer Vaccines

871
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
871
Cancer Therapies02:49

Cancer Therapies

9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

6.3K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multivalent DNA vaccines induce potent cellular responses and prolong BCG-mediated control of Mycobacterium tuberculosis.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Surgical-site infections in infants undergoing surgery for congenital heart disease during their first year of life.

JTCVS open·2026
Same author

Scrolling for science: Assessing the quality and accuracy of Crohn's disease-related content on Instagram reels.

PloS one·2026
Same author

Guidewire-Induced Pseudostenosis of the Iliac Artery During Chronic Total Occlusion Percutaneous Coronary Intervention.

JACC. Case reports·2026
Same author

Paraneoplastic pemphigus in primary peritoneal clear cell carcinoma: a multidisciplinary management approach.

Gynecologic oncology reports·2026
Same author

Deep mining of the human antibody repertoire identifies frequent and genetically diverse CDRH3 topologies targetable by vaccination.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Dec 23, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.6K

Immuno-oncology for Gynecologic Malignancies.

Jeffrey How1, Ami Patel1, Amir Jazaeri2

  • 1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Advances in Experimental Medicine and Biology
|April 18, 2020
PubMed
Summary

Immunotherapy shows promise for gynecologic cancers, offering new hope beyond traditional treatments. Clinical trials are rapidly expanding to explore these innovative immune checkpoint inhibitor therapies.

Keywords:
Adoptive cell transferCancer vaccinesCervical cancerEndometrial cancerImmune checkpoint inhibitorsImmunotherapyOvarian cancer

More Related Videos

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

2.7K
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
10:35

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

Published on: November 28, 2010

18.7K

Related Experiment Videos

Last Updated: Dec 23, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.6K
Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

2.7K
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
10:35

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

Published on: November 28, 2010

18.7K

Area of Science:

  • Gynecologic Oncology
  • Cancer Immunotherapy
  • Clinical Trials

Background:

  • Current treatments for advanced/recurrent gynecologic cancers offer limited patient benefit.
  • Successful immunotherapy in other cancers spurs interest in gynecologic malignancies.
  • Limited FDA-approved immunotherapy options exist for gynecologic cancers.

Purpose of the Study:

  • To review major reported and ongoing immunotherapy clinical trials.
  • To explore immunotherapy approaches in endometrial, cervical, and ovarian cancers.
  • To assess the potential of immunotherapy in gynecologic oncology.

Main Methods:

  • Review of published data on immunotherapy clinical trials.
  • Analysis of ongoing clinical trials in gynecologic cancers.
  • Focus on immune checkpoint inhibitors, chemotherapy, and targeted agents.

Main Results:

  • Exponential growth in immunotherapy clinical trials for gynecologic cancers.
  • Current FDA approvals are restricted to specific cancer types (microsatellite instable, PD-L1-positive cervical).
  • Combination therapies (immunotherapy with chemo/targeted agents) are under investigation.

Conclusions:

  • Immunotherapy represents a significant area of research for gynecologic cancers.
  • Further clinical trials are crucial to establish efficacy and expand treatment options.
  • Hope for improved outcomes in advanced/recurrent gynecologic cancers is increasing.