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Intrauterine insemination: a European collaborative report
1Department of Obstetrics and Gynaecology, University Hospital, Trondheim, Norway.
Human Reproduction (Oxford, England)
|October 1, 1988
Summary
Intrauterine insemination (IUI) with pretreated sperm resulted in an 8.4% pregnancy rate per cycle across European clinics. While IUI showed comparable results to IVF for male infertility, no single factor explained varied success rates.
Area of Science:
- Reproductive Medicine
- Infertility Treatment
- Sperm Preparation Techniques
Background:
- Intrauterine insemination (IUI) is a common infertility treatment.
- Pretreatment of sperm is often employed to improve IUI outcomes.
- Variability in IUI success rates necessitates data collection and analysis.
Purpose of the Study:
- To summarize data on intrauterine insemination (IUI) with pretreated sperm from European clinics.
- To analyze pregnancy rates and outcomes associated with IUI for different infertility causes.
- To identify factors influencing IUI success rates.
Main Methods:
- A questionnaire was distributed to European infertility clinics regarding IUI methods and results.
- Data from 29 clinics were evaluated, with 20 clinics reporting pregnancy data.
- Pregnancy rates, abortion rates, and birth outcomes were analyzed per treatment cycle.
Main Results:
- An overall pregnancy rate of 8.4% per IUI cycle was reported.
- Specific rates included 7.4% for male infertility, 10.8% for hostile cervical mucus, and 12.9% for idiopathic infertility.
- The clinical abortion rate averaged 12.2%, with 127 reported births and a male/female sex ratio of 0.512.
Conclusions:
- Intrauterine insemination (IUI) with pretreated sperm yields an average pregnancy rate of 8.4% per cycle.
- IUI demonstrated comparable efficacy to in vitro fertilization (IVF) for male infertility in some clinics.
- No specific procedural factor was identified as solely responsible for the observed variations in IUI pregnancy rates among clinics.