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Pharmacotherapeutic Options for Chronic Refractory Cough
Woo-Jung Song1,2, Kian Fan Chung2
1Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Expert Opinion on Pharmacotherapy
|April 18, 2020
Summary
Novel drugs targeting cough reflex pathways show promise for chronic refractory cough (CRC). While current treatments have limitations, new therapies aim to control cough hypersensitivity effectively and safely.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Neuroscience
Background:
- Chronic refractory cough (CRC) significantly impairs quality of life.
- Advances in neurobiology reveal CRC can be managed by targeting cough reflex pathways.
Purpose of the Study:
- To review clinical trials of antitussives for CRC.
- To discuss ongoing trials of novel antitussive drugs.
- To identify knowledge gaps in CRC treatment.
Main Methods:
- Overview of existing clinical trial data for CRC antitussives.
- Analysis of ongoing clinical trials for novel CRC medications.
- Discussion of drug efficacy, safety, and limitations.
Main Results:
- Current antitussives (opioids, gabapentin) have efficacy and safety limitations.
- First-in-class P2X3 antagonist gefapixant shows promise.
- Early trials target cough reflex pathways to control hypersensitivity.
Conclusions:
- Novel drugs targeting cough reflex pathways offer potential for CRC.
- Further research is needed to optimize treatment strategies.
- Biomarkers are required to predict patient response to antitussives.
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