Related Experiment Video
Updated: Dec 23, 2025
11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
16.5K
Delayed patch test reaction to budesonide in an 8-year-old
Pediatric Dermatology
|April 18, 2020
Summary
Topical corticosteroids can cause allergic contact dermatitis in children, often missed by doctors. Delayed patch testing reactions, like the one to budesonide in this case, are crucial for accurate diagnosis.
Area of Science:
- Allergen immunotherapy
- Pediatric dermatology
- Contact dermatitis
Background:
- Topical corticosteroids are frequently used to treat pediatric dermatitis.
- Allergic contact dermatitis (ACD) from topical corticosteroids is an underdiagnosed cause of persistent or worsening skin conditions in children.
- Standard patch testing protocols may miss delayed hypersensitivity reactions.
Observation:
- A case study of an 8-year-old girl with persistent dermatitis despite topical corticosteroid use is presented.
- The patient underwent patch testing to identify potential allergens.
- A delayed positive reaction to budesonide was observed on day 12 of patch testing.
Findings:
- Delayed hypersensitivity reactions (>7 days) to topical corticosteroids can occur.
- These delayed reactions may lead to false-negative results in standard patch testing.
- Budesonide elicited a positive reaction on day 12 in the reported pediatric case.
Implications:
- Consider patch testing for topical corticosteroids in children with refractory dermatitis.
- Extended patch testing durations may be necessary to detect delayed reactions.
- Accurate diagnosis of corticosteroid allergy is vital for appropriate management and preventing misdiagnosis.
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