Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Universal and Cross-Cultural Variations in Audio-Motor Synchronization Between French and Indian Participants.

Annals of the New York Academy of Sciences·2026

Same author

On Intention and Fluctuations in the Coordination Dynamics of Animate Movement.

Entropy (Basel, Switzerland)·2026

Same author

Model-based analysis of stop-signal data reveals robust neural and clinical correlates of evidence accumulation but not inhibition.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Same author

Advancing EEG-based assessment of consciousness and cognition in prolonged disorders of consciousness.

Communications medicine·2026

Same author

Bullying victimization and brain development: a longitudinal structural magnetic resonance imaging study from adolescence to early adulthood.

Translational psychiatry·2026

Same author

A longitudinal DNA methylation atlas and its link to brain structure and mental health.

Molecular psychiatry·2026

Search research articles

Related Experiment Video

Updated: Dec 23, 2025

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

Metastable neural dynamics underlies cognitive performance across multiple behavioural paradigms.

Thomas H Alderson^1,2, Arun L W Bokde³, J A Scott Kelso^1,4

¹Intelligent Systems Research Centre, Ulster University, Antrim, United Kingdom.

Human Brain Mapping

|April 18, 2020

Summary

Brain network metastability, particularly in cognitive control networks, is linked to fluid intelligence and problem-solving. Spontaneous brain activity patterns, rather than task-induced changes, best predict cognitive performance.

Keywords:

cognition coordination dynamics deep learning fMRI metastability metastable neural dynamics neurocognitive networks resting state

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

Related Experiment Videos

Last Updated: Dec 23, 2025

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

Area of Science:

Neuroscience
Cognitive Science
Computational Neuroscience

Background:

Resting state networks (RSNs) are linked to cognitive abilities, but their coordinated function remains unclear.
Metastability in RSN coordination dynamics may integrate local brain areas into large-scale networks.
This integration is hypothesized to confer behavioral advantages.

Purpose of the Study:

To investigate the role of brain network metastability in cognitive function.
To compare network metastability at rest versus during cognitive tasks.
To determine if spontaneous or task-induced metastability better predicts cognitive ability.

Main Methods:

Analysis of functional magnetic resonance imaging (fMRI) data from 566 healthy individuals.
Estimation of metastability using a phase-locking collective variable for large-scale RSNs.
Comparison of metastability during rest and various cognitive tasks.

Main Results:

Task-based reasoning showed high metastability in cognitive control networks and low metastability in sensory areas.
Metastability between RSNs increased during tasks, but cognitive ability correlated more strongly with spontaneous activity.
High metastability in intrinsic connectivity of cognitive control networks predicted fluid intelligence and novel problem-solving.

Conclusions:

Spontaneous metastability in large-scale cortical networks is crucially linked to cognitive abilities.
Pre-configured resting brain architectures facilitate superior cognitive performance.
Metastability dynamics offer insights into the neural basis of cognition.