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Coronary artery bypass surgery independently associates with retinal vascular oxygen saturation

Sebastian Dinesen1, Pia S Jensen2, Maria Bloksgaard3

  • 1Department of Ophthalmology, Odense University Hospital, Odense, Denmark.

Acta Ophthalmologica
|April 18, 2020
PubMed

Insights

Coronary artery bypass grafting (CABG) is linked to altered retinal vascular oxygen saturation. These retinal measurements may serve as non-invasive markers for coronary artery disease.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Medical Imaging

Background:

  • The retinal vasculature offers a unique window into systemic microcirculation.
  • Investigating systemic circulation through retinal vessels can reveal cardiovascular health indicators.

Purpose of the Study:

  • To determine if coronary artery bypass grafting (CABG) surgery is associated with changes in retinal vascular oxygen saturation (rSatO2).
  • To explore the potential of rSatO2 as a non-invasive marker for coronary artery disease.

Main Methods:

  • Retinal metabolism was assessed using Oxymap T1, measuring arteriolar (raSatO2) and venular (rvSatO2) oxygen saturation.
  • Measurements were taken 3-4 days post-CABG in 38 patients and compared to 39 healthy controls.

Main Results:

  • CABG patients exhibited significantly higher raSatO2 (93.1% vs 90.5%) and rvSatO2 (57.4% vs 53.5%) compared to controls.
  • Multivariable analysis confirmed that raSatO2 and rvSatO2 were independently associated with CABG.

Conclusions:

  • Retinal arteriolar and venular oxygen saturation are positively associated with CABG.
  • These findings suggest that rSatO2 could be a valuable non-invasive biomarker for coronary large artery disease.
Abstract

Keywords:
CABGimagingoxygen metabolismretinal microcirculationretinal oximetry

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