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Related Concept Videos

Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

6.2K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
6.2K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

13.2K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
13.2K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.7K
Bone Remodeling01:40

Bone Remodeling

40.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.1K
Compact Bone01:27

Compact Bone

15.7K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
15.7K

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Related Experiment Video

Updated: Dec 23, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

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Basic and clinical associations between bone and cancer.

Fang He1, Yoshinori Matsumoto1

  • 1Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.

Immunological Medicine
|April 18, 2020
PubMed
Summary
This summary is machine-generated.

Bone metastasis, a common cancer spread, causes pain and fractures. This review explores the molecular mechanisms driving bone metastasis and therapeutic strategies targeting bone metabolism.

Keywords:
Bone metastasesbisphosphonatesdenosumab

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Last Updated: Dec 23, 2025

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Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
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Area of Science:

  • Oncology
  • Pathology
  • Immunology

Background:

  • Bone is a frequent site for cancer metastasis, significantly impacting patient quality of life.
  • Bone metastases manifest as osteolytic, osteoblastic, or mixed types, dictated by primary cancer cell biology.
  • The complex interplay between the immune system and bone microenvironment influences tumor cell spread to bone.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying bone metastasis.
  • To review therapeutic strategies for bone metastasis, emphasizing bone metabolism.
  • To provide insights into the pathological classification of bone metastases.

Main Methods:

  • Literature review of molecular mechanisms in bone metastasis.
  • Analysis of therapeutic strategies focusing on bone metabolism.
  • Discussion of pathological classifications of bone metastases.

Main Results:

  • Detailed exploration of molecular pathways driving cancer cell colonization and growth in bone.
  • Identification of key factors within the bone microenvironment that support metastasis.
  • Overview of current and emerging therapeutic approaches targeting bone metabolism.

Conclusions:

  • Understanding molecular mechanisms is crucial for developing effective bone metastasis treatments.
  • Targeting bone metabolism offers a promising therapeutic avenue for managing bone metastases.
  • Accurate classification of bone metastasis types guides treatment selection.