Related Experiment Video
Updated: Dec 23, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Cutaneous T-cell lymphoma: aetiopathogenesis and current diagnostic and therapeutic developments
Marianna Papadaki1, Konstantina Saraki1, Fani Karagianni1
12nd Department of Dermatology and Venereal Diseases, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Abstract:
Cutaneous T-cell lymphoma is a heterogeneous group of non-Hodgkin's lymphoma, characterized by an infiltration of malignant T cells in the skin. The most common subgroups include mycosis fungoides followed by the aggressive leukaemic variant, Sézary syndrome. The pathophysiology of this neoplasm is poorly understood. The diagnosis of mycosis fungoides at the early stages can be challenging due to phenotypic similarities with other skin conditions. A lack of understanding of the aetiopathology of this neoplasia makes prognosis and diagnosis, as well as the development of targeted therapies aimed at long remission, challenging. This review provides an update on the aetiopathology of cutaneous T-cell lymphoma with regards to genetic and epigenetic alterations, current diagnostic tools and treatments, as well as emerging therapies.
More Related Videos
09:15Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
09:53Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
Published on: February 6, 2017
Related Concept Videos
Tumor Immunotherapy
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...