Surface Contamination With Antineoplastic Drugs on Two Inpatient Oncology Units.

Area of Science:

• Oncology Nursing
• Environmental Contamination
• Occupational Health

Background:

• Inpatient oncology units pose risks of surface contamination with hazardous antineoplastic drugs.
• Understanding nursing staff's personal protective equipment (PPE) use is crucial for mitigating exposure risks.

Purpose of the Study:

• To quantify surface contamination levels of antineoplastic drugs in inpatient oncology settings.
• To assess personal protective equipment (PPE) usage among nursing staff and identify predictive factors.

Main Methods:

• A descriptive pilot study was conducted on two inpatient oncology units.
• Surface samples were analyzed for etoposide and cyclophosphamide using liquid chromatography tandem mass spectrometry.
• Nursing staff (N=27) completed online surveys on PPE use and influencing factors.

Main Results:

• Cyclophosphamide and etoposide contamination were detected on 61% and 31% of surfaces, respectively.
• Nursing staff reported inadequate PPE use during drug administration, disposal, and patient excreta handling.
• A positive workplace safety climate predicted higher PPE use.

Conclusions:

• Significant surface contamination with antineoplastic drugs presents exposure risks in oncology units.
• Interventions should target high-contamination areas, such as toilet seats, and promote consistent PPE use.
• Improving workplace safety climate may enhance adherence to protective measures.