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GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells.

Alexandra Gunne-Braden1, Adrienne Sullivan1, Borzo Gharibi1

  • 1The Francis Crick Institute, London, UK.

Cell Stem Cell
|April 18, 2020
PubMed
Summary

Human embryonic stem cells commit to differentiation much earlier than expected. Positive feedback between GATA3 and bone morphogenetic protein 4 (BMP4) drives this irreversible commitment, revealing key insights into early cell fate decisions.

Keywords:
BMP4GATA3bistabilitycommitmentdifferentiationfate decisionshESCpositive feedback

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