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Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia.

Joel H L Tan1, Heike Wollmann2, Ans M M van Pelt3

  • 1Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore 119077, Singapore.

Stem Cell Reports
|April 18, 2020
PubMed
Summary

Trim28 gene haploinsufficiency in mice disrupts spermatogonial stem cell (SSC) balance, leading to testicular degeneration and infertility. Reduced Trim28 levels promote SSC differentiation over self-renewal.

Keywords:
KAP1TRIM28fertilityhaploinsufficiencyinfertilityspermatogenesisspermatogonial stem cells

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