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Related Concept Videos

Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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SLeuthing Tuberculous Cough.

Marcel A Behr1, Paul H Edelstein2, Lalita Ramakrishnan3

  • 1Department of Medicine, McGill University, McGill International TB Centre, Montreal H4A 3J1, Canada.

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Summary
This summary is machine-generated.

A tuberculosis-specific lipid, SL-1, stimulates cough-inducing neurons in humans and guinea pigs. Mycobacterium tuberculosis extracts also activate other neurons involved in the cough reflex, indicating complex mechanisms.

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Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Immunology

Background:

  • Cough is a primary symptom and transmission route for tuberculosis (TB).
  • The neural mechanisms underlying TB-induced cough are not fully understood.
  • Mycobacterium tuberculosis (Mtb) is the causative agent of TB.

Purpose of the Study:

  • To investigate the role of Mtb-specific lipids in stimulating cough-related neurons.
  • To identify neural pathways activated by Mtb components contributing to the cough reflex.

Main Methods:

  • Electrophysiological recordings from human nociceptive neurons.
  • Cough induction assays in guinea pig models.
  • Stimulation with Mtb-specific lipid SL-1 and Mtb extracts.

Main Results:

  • The Mtb-specific lipid SL-1 directly stimulates human nociceptive neurons.
  • SL-1 administration induced coughing in guinea pigs.
  • Mtb extracts stimulated both nociceptive and non-nociceptive neurons involved in the cough reflex.

Conclusions:

  • Mtb lipid SL-1 is a key mediator of TB-induced cough by activating nociceptive neurons.
  • Additional Mtb components activate other neural pathways, suggesting multifaceted mechanisms in TB-related cough.