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Related Experiment Video

Updated: Dec 23, 2025

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome

Published on: April 2, 2018

Molecular profiling for acromegaly treatment: a validation study.

Manel Puig-Domingo^1,2,3,4, Joan Gil², Miguel Sampedro-Nuñez^4,5

¹Department of Endocrinology and Nutrition, Germans Trias i Pujol University Hospital, Badalona, Spain.

Endocrine-Related Cancer

|April 18, 2020

Summary

This summary is machine-generated.

E-cadherin is a promising molecular marker for predicting patient response to somatostatin receptor ligands (SRL) in acromegaly treatment. This finding could improve personalized therapeutic strategies for acromegaly patients who do not respond adequately to current treatments.

Keywords:

E-cadherin Ki-67 SSTR2 acromegaly predictive response somatostatin analogues somatostatin receptor ligands (SRL)

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Last Updated: Dec 23, 2025

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Published on: September 13, 2022

Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Pharmacologic treatment for acromegaly primarily uses somatostatin receptor ligands (SRL), but approximately 50% of patients exhibit inadequate response.
Understanding molecular predictors of SRL response is crucial for optimizing acromegaly management.

Purpose of the Study:

To evaluate various molecular markers for their potential to predict patient response to somatostatin receptor ligands (SRL) in acromegaly.
To identify biomarkers that can guide treatment decisions in patients with inadequate SRL response.

Main Methods:

Analysis of somatotropinoma tissue from 100 acromegalic patients using RT-qPCR and Sanger sequencing.
Assessed expression of SSTR2, SSTR5, AIP, E-cadherin (CDH1), Ki-67 (MKI67), and other genes.
Categorized SRL response as complete, partial, or non-response based on IGF1 levels at 6 months.

Main Results:

E-cadherin (CDH1), Ki-67 (MKI67), and SSTR2 expression levels were significantly associated with SRL response.
E-cadherin demonstrated the highest predictive value (AUC = 0.74) for SRL response, validated at the protein level.
SSTR5 expression was elevated in patients previously treated with SRL before surgery.

Conclusions:

Somatotropinomas exhibit molecular heterogeneity influencing SRL response.
E-cadherin is identified as the most effective molecular predictor for SRL response in acromegaly.
Incorporating E-cadherin assessment may enhance treatment decision-making after surgical failure in acromegaly.