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Updated: Dec 23, 2025

Purification of a High Molecular Mass Protein in Streptococcus mutans
Published on: September 14, 2019
Effects of resveratrol on cariogenic virulence properties of Streptococcus mutans
Jinheng Li1, Tiantian Wu1, Weiwei Peng1
1Department of General Dentistry, College of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, 639 Zhi Zao Ju Road, Shanghai, 200011, China.
Background:
Streptococcus mutans is the principal etiological agent of human dental caries. The major virulence factors of S. mutans are acid production, acid tolerance, extracellular polysaccharide (EPS) synthesis and biofilm formation. The aim of this study is to evaluate the effect of resveratrol, a natural compound, on virulence properties of S. mutans.
Results:
Resveratrol at sub-MIC levels significantly decreased acid production and acid tolerance, inhibited synthesis of water-soluble polysaccharide and water-insoluble polysaccharide, compromised biofilm formation. Related virulence gene expression (ldh, relA, gtfC, comDE) was down-regulated with increasing concentrations of resveratrol.
Conclusions:
Resveratrol has an inhibitory effect on S. mutans cariogenic virulence properties and it represents a promising anticariogenic agent.
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