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Updated: Dec 23, 2025

Generation of Human Kidney Tubuloids from Tissue and Urine
Published on: April 16, 2021
The Utility of Human Kidney Organoids in Modeling Kidney Disease
Aneta Przepiorski1, Amanda E Crunk1, Eugenel B Espiritu1
1Department of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
Abstract:
The formation of three-dimensional kidney tissue (organoids) from human pluripotent stem cell lines provides a valuable tool to examine kidney function in an in vitro model and could be used for regenerative medicine approaches. Kidney organoids have the potential to model kidney diseases and congenital defects, be used for drug development, and to further our understanding of acute kidney injury, fibrosis, and chronic kidney disease. In this review, we examine the current stage of pluripotent stem cell-derived kidney organoid technology, challenges, shortcomings, and regenerative potential of kidney organoids in the future.

