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Updated: Dec 23, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
What Do We Know About Clodronate Now? A Medical and Veterinary Perspective
Richard Markell1, Gianantonio Saviola2, Elizabeth Ann Barker3
1Ranch & Coast Equine Practice, Inc, Bonsall, CA; IlluminX Consulting Inc, Bonsall, CA.
Abstract:
There has recently been some controversy over the use of bisphosphonates in horses and some confusion regarding the different classes of bisphosphonates and the differences between the mechanism of actions and effects of each class. This review article explores the different bisphosphonate classes and their different effects and mechanisms of action based on research from both the human and equine veterinary fields. This collaborative review between veterinary surgeons and medical doctors describes the latest use of bisphosphonates in humans and horses, including safety aspects, and allows comparisons to be drawn between the two fields. Potential future uses of bisphosphonates are also discussed.
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