Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 23, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.1K

Metronidazole-associated Neurologic Events: A Nested Case-control Study.

Nick Daneman1,2,3,4, Yi Cheng1, Tara Gomes1,5

  • 1ICES, Toronto, Ontario, Canada.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|April 19, 2020
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimating the daily milligrams of morphine equivalent of illicit fentanyl use in Los Angeles: Clinical and epidemiological implications.

Drug and alcohol dependence·2026
Same author

Geographic variation and neighbourhood correlates of mental health-related hospitalizations and emergency department visits in children and youth during the COVID-19 pandemic: a population-based study.

Frontiers in child and adolescent psychiatry·2026
Same author

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.

Clinical pharmacology and therapeutics·2026
Same author

Estimating the Daily Milligrams of Morphine Equivalent of Illicit Fentanyl Use in Los Angeles: Clinical and Epidemiological Implications.

medRxiv : the preprint server for health sciences·2026
Same author

Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study.

PLoS medicine·2026
Same author

Infant deaths in the EudraVigilance database.

British journal of clinical pharmacology·2026

Metronidazole use is linked to a higher risk of nervous system issues compared to clindamycin. Patients and doctors should monitor for these rare but serious side effects.

Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Medicine

Background:

  • Case reports suggest metronidazole may cause nervous system toxicity.
  • Large-scale studies investigating this association are lacking.

Purpose of the Study:

  • To investigate the association between metronidazole use and nervous system adverse events.
  • To compare the risk of neurologic events between metronidazole and clindamycin users.

Main Methods:

  • Population-based nested case-control study in Ontario, Canada (2003-2017).
  • Included adults aged 66+ who received metronidazole or clindamycin.
  • Cases had hospital admission for neurologic events; controls were matched.

Main Results:

Keywords:
cerebellar syndromeencephalopathymetronidazoleperipheral neuropathypharmacoepidemiology

More Related Videos

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

232
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION
06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION

Published on: November 20, 2016

9.2K

Related Experiment Videos

Last Updated: Dec 23, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.1K
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

232
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION
06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION

Published on: November 20, 2016

9.2K
  • 1212 cases and 12,098 controls identified.
  • Metronidazole use was associated with increased odds of neurologic events (aOR 1.43).
  • Association observed for both central and peripheral nervous system events.

    • Conclusions:

    • Metronidazole is associated with an increased risk of peripheral and central nervous system events compared to clindamycin.
    • Clinicians and patients should be aware of these potential adverse events.