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A Fully Automatic Method for Optic Radiation Tractography Applicable to Multiple Sclerosis Patients.

Jean-Baptiste Davion1,2, Gregory Kuchcinski3,4, Romain Viard4

  • 1Centre de référence des Maladies Neuromusculaires, CHU Lille, 59000, Lille, France. jeanbaptiste.davion@chru-lille.fr.

Brain Topography
|April 19, 2020
PubMed
Summary

A new automatic method accurately maps optic radiations (OR) using MRI tractography. This technique shows high precision in healthy subjects and applicability in multiple sclerosis patients, outperforming atlas-based approaches for lesion volume correlation.

Keywords:
MRIMultiple sclerosisOptic radiationsTractography

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Area of Science:

  • Neuroimaging
  • Neuroanatomy
  • White Matter Tracts

Background:

  • Optic radiations (OR) are crucial white matter tracts in the visual pathway.
  • Inter-individual variability makes traditional atlas-based localization of OR inefficient.
  • Accurate delineation of OR is essential for understanding visual pathway disorders.

Purpose of the Study:

  • To develop and validate a fully automatic magnetic resonance imaging (MRI) tractography method for delimiting the optic radiations (OR).
  • To assess the method's accuracy, reproducibility, and feasibility in healthy subjects and multiple sclerosis (MS) patients.
  • To compare the clinical relevance of OR lesion volume measurements using the new method versus existing approaches.

Main Methods:

  • A fully automatic tractography method was designed to reconstruct the OR on MRI data.
  • Method validation involved comparison with a post-mortem histological atlas and reproducibility assessments in 15 healthy subjects.
  • Feasibility was evaluated in 98 MS patients, correlating inflammatory lesion volume within the OR with visual outcomes.

Main Results:

  • The automatic method successfully reconstructed OR in all healthy subjects with high classification indexes (sensitivity 0.996, specificity 0.993, Dice 0.842, ROC AUC 0.981).
  • Reproducibility was confirmed, and the method was feasible in 92.9% of MS patients.
  • Lesion volume in OR, measured by the new method, showed stronger correlations with visual cortex volume, visual acuity, and retinal nerve fiber layer thickness than atlas or TractSeg methods.

Conclusions:

  • The developed automatic tractography method is efficient and reproducible for OR reconstruction in healthy individuals.
  • The method is applicable to MS patients and offers a more clinically relevant assessment of OR damage compared to atlas-based methods.
  • This automated approach may improve the understanding and management of visual pathway disorders like MS.