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Lipidomics and Transcriptomics in Neurological Diseases

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Bioactive Lipids in Age-Related Disorders.

Undurti N Das^1,2

¹UND Life Sciences, Battle Ground, WA, USA. undurti@lipidworld.com.

Advances in Experimental Medicine and Biology

|April 19, 2020

Summary

Defects in essential fatty acid metabolism contribute to age-related diseases by disrupting bioactive lipid production. Restoring these lipids may prevent disease and promote healthy aging.

Keywords:

Aging Atherosclerosis Bioactive lipids Cancer Coronary heart disease Diabetes mellitus Diseases Disorders Hypertension Immune dysfunction Lupus Nephritis Retinopathy Rheumatoid arthritis

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Area of Science:

Biochemistry
Molecular Biology
Gerontology

Background:

Essential fatty acid (EFA) metabolism defects are linked to numerous age-related disorders.
These include obesity, diabetes, hypertension, atherosclerosis, heart disease, immune dysfunction, and cancer.

Purpose of the Study:

To investigate the role of EFA metabolism defects in age-related diseases.
To explore the connection between enzyme activity, bioactive lipid (BAL) production, and inflammation.

Main Methods:

Analysis of EFA metabolism pathways.
Examination of desaturase, cyclo-oxygenase (COX), and lipoxygenase (LOX) enzyme activities.
Assessment of bioactive lipid (BAL) profiles.

Main Results:

Defects in EFA metabolism lead to reduced production of beneficial long-chain fatty acids (e.g., GLA, EPA, DHA).
This results in increased pro-inflammatory mediators (PGE2, TXs, LTs) and decreased anti-inflammatory mediators (lipoxins, resolvins).
Imbalance in BALs drives low-grade systemic inflammation, contributing to age-related diseases.

Conclusions:

Restoring normal bioactive lipid (BAL) levels is a potential strategy for preventing age-related disorders.
Interventions targeting EFA metabolism could enhance longevity and healthspan.