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Programmed cell death protein 1 (PD-1) in infection

Steffen Leth1, Søren Jensen-Fangel1

  • 1Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|April 19, 2020
PubMed

Insights

Inhibiting immune checkpoint pathways can help fight infections, similar to cancer treatment. Further research is needed to develop safe and effective strategies for patients with infectious diseases.

Area of Science:

  • Immunology
  • Oncology
  • Infectious Diseases

Background:

  • T cell exhaustion and dysfunction impair the immune response against infections and cancer.
  • Blocking inhibitory immune checkpoints has proven effective in treating various cancers.

Purpose of the Study:

  • To review the potential of inhibiting immune checkpoint pathways for controlling or clearing infectious diseases.
  • To highlight the need for further research in translating these strategies for clinical use in infections.

Main Methods:

  • Review of emerging evidence on immune checkpoint inhibition in infectious diseases.
  • Analysis of current research trends and clinical relevance.

Main Results:

  • Immune checkpoint inhibition shows promise in preclinical and some clinical studies for infectious diseases.
  • Significant challenges remain in optimizing safety and efficacy for clinical application.

Conclusions:

  • Inhibiting immune checkpoint pathways is a potential therapeutic strategy for infectious diseases.
  • Development of safe and clinically translatable strategies requires substantial further investigation.
Keywords:
Checkpoint inhibitorsPD-1exhausted T cellsimmunologyinfection

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