Related Experiment Video

Updated: Dec 23, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.2K

Globe Axial Length Growth at Age 10.5 Years in the Infant Aphakia Treatment Study

M Edward Wilson1, Rupal H Trivedi1, David R Weakley2

  • 1Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA.

American Journal of Ophthalmology
|April 19, 2020
PubMed

Insights

Infant cataract surgery did not alter overall axial length (AL) growth compared to fellow eyes. Treated eyes showed similar growth whether treated with contact lenses (CL) or intraocular lenses (IOL), though glaucoma impacted AL growth.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Ophthalmic Surgery

Background:

  • Unilateral cataract surgery in infants requires monitoring of axial length (AL) growth.
  • The Infant Aphakia Treatment Study provides long-term data on visual development and ocular growth.

Purpose of the Study:

  • To track changes in globe axial length (AL) from infancy to age 10.5 years after unilateral cataract surgery.
  • To compare AL growth between operated and fellow unoperated eyes in infants.

Main Methods:

  • A comparative case series design was used.
  • Axial length growth was analyzed based on treatment type (contact lens vs. intraocular lens), visual acuity outcomes, and need for secondary surgery.
  • Eyes with glaucoma were analyzed separately.

Main Results:

  • Treated eyes were shorter preoperatively and at age 10.5 but exhibited similar AL growth (4.7 mm) to fellow eyes (P = .99).
  • Axial length growth was comparable between contact lens and intraocular lens groups (P = .79).
  • Eyes with glaucoma showed significantly greater growth (7.3 mm) compared to non-glaucomatous eyes (4.7 mm).

Conclusions:

  • Unilateral cataract surgery in infants does not significantly alter overall axial length growth compared to fellow eyes.
  • Axial length growth was similar for both contact lens and intraocular lens treatments.
  • Glaucoma and poor visual acuity were associated with increased axial length growth in operated eyes.
Abstract

More Related Videos

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses07:56

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses

Published on: May 3, 2016

7.6K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.3K

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
887
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.3K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K