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Related Experiment Video

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Simultaneous multi-slice T1 mapping using MOLLI with blipped CAIPIRINHA bSSFP.

Zakarya Bentatou1, Thomas Troalen2, Monique Bernard3

  • 1Aix Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France; Siemens Healthcare SAS, Saint-Denis, France.

Magnetic Resonance Imaging
|April 19, 2020
PubMed
Summary

Amplitude-only RF modulation (AM) reduces artefacts in simultaneous multi-slice (SMS) T1 mapping, enabling single breath-hold cardiac imaging. This technique provides accurate T1 quantification comparable to conventional methods.

Keywords:
Amplitude-only modulationBlipped-CAIPIRINHACAIPIRINHAMOLLISimultaneous multi-sliceT1 mappingWong modulationbSSFP

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Area of Science:

  • Magnetic Resonance Imaging
  • Cardiac Imaging
  • Quantitative MRI

Background:

  • Conventional MOLLI cardiac T1 mapping requires 3 slices and 3 breath-holds.
  • Simultaneous multi-slice (SMS) techniques offer potential for faster imaging but can introduce artefacts.
  • Side-lobe excitations in SMS-bSSFP MOLLI sequences cause artefacts due to RF modulation and bSSFP signal profiles.

Purpose of the Study:

  • To evaluate single breath-hold 3 simultaneous multi-slice (SMS3) T1 mapping as a replacement for conventional MOLLI.
  • To compare Amplitude-only RF modulation (AM) with Wong multi-band RF modulation (WM) for artefact reduction in SMS-MOLLI.
  • To assess the accuracy and feasibility of AM-SMS-bSSFP MOLLI for in vivo T1 quantification.

Main Methods:

  • Phantoms and 10 healthy volunteers were imaged at 1.5T using blipped-CAIPIRINHA SMS-bSSFP MOLLI.
  • Compared conventional single-slice (SMS1) MOLLI with WM-SMS3 and AM-SMS3.
  • Assessed SNR, T1 accuracy in phantoms, and evaluated artefacts in a fat-mimicking phantom and in volunteers.

Main Results:

  • AM RF pulses reduced side-lobe artefacts by 38% compared to WM.
  • In volunteers, AM-SMS3-MOLLI showed similar artefact reduction to WM-SMS3-MOLLI (3 vs 5 corrupted LV segments).
  • In vivo native and postcontrast T1 values from AM-SMS3-MOLLI were equivalent to conventional SMS1-MOLLI in LV myocardium and blood pool.

Conclusions:

  • Amplitude-only RF modulation (AM) significantly reduces side-lobe artefacts in SMS-bSSFP MOLLI.
  • AM-SMS-bSSFP MOLLI shows promise for single breath-hold cardiac imaging with accurate T1 quantification.
  • The blipped-CAIPIRINHA MOLLI T1 mapping sequence provides accurate in vivo T1 quantification comparable to single-slice acquisition.