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Amino and hydroxy substitution influences pyrene-DNA binding

Chao Qin1, Xiaojie Hu1, Michael Gatheru Waigi1

  • 1Institute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.

The Science of the Total Environment
|April 19, 2020
PubMed
Summary

Amino (-NH2) substitution greatly enhanced polycyclic aromatic hydrocarbon (PAH)-DNA binding, while hydroxy (-OH) substitution inhibited it. This clarifies how functional groups affect PAH interactions with DNA, crucial for understanding carcinogenesis.

Keywords:
CarcinogenesisDNAFunctional groupsPAHs

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