Related Experiment Video
Updated: Dec 23, 2025

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
Published on: April 6, 2022
Natural compounds flavonoids as modulators of inflammasomes in chronic diseases
Brice Ayissi Owona1, Wilfred Angie Abia1, Paul Fewou Moundipa1
1Department of Biochemistry, Laboratory of Molecular Pharmacology and Toxicology, PO 812 AEFAS Faculty of Science, University of Yaounde I, Cameroon.
Abstract:
The use of dietary or medicinal plant based natural compounds to disease treatment has become a unique trend in clinical research. Flavonoids, a group of polyphenolic compounds have drawn significant attention due to their modulatory effects on inflammasomes associated with the initiation and progression of chronic disorders including metabolic, neurodegenerative diseases and cancer. In this article, the role of most commonly studied natural flavonoids with their disease-specific impact via inflammasomes as a potential molecular target has been described. Since the role of inflammation is evident in multiple diseases, flavonoids may serve as a promising tool in drug discovery for the intervention of chronic diseases by manipulating the status of inflammation via inflammasome targeting.
More Related Videos
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
The JAK-STAT Signaling Pathway
Inflammatory Response I: Vascular and Cellular
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

