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Prostatic Artery Embolization for Benign Prostatic Hyperplasia: Bleomycin-Eluting versus Bland Microspheres in a
Jin Long Zhang1, Bing Yuan1, Mao Qiang Wang1
1Department of Interventional Radiology, Chinese PLA General Hospital, 28 Fu-xing Rd., Beijing 100853, P.R. China.
Journal of Vascular and Interventional Radiology : JVIR
|April 20, 2020
Summary
Prostatic artery embolization (PAE) with bleomycin-eluting microspheres effectively reduced prostate volume in a canine model. This novel PAE approach demonstrated safety and efficacy for treating benign prostatic hyperplasia (BPH).
Area of Science:
- Interventional Radiology
- Urology
- Biomedical Engineering
Background:
- Benign prostatic hyperplasia (BPH) is a common condition in aging men.
- Current treatments for BPH have limitations and potential side effects.
- Prostatic artery embolization (PAE) is an emerging minimally invasive treatment for BPH.
Purpose of the Study:
- To evaluate the safety and efficacy of PAE using bleomycin-eluting microspheres in a canine model.
- To compare bleomycin-eluting microspheres with bland microspheres for PAE in BPH treatment.
- To assess prostate volume reduction and ischemic changes following PAE.
Main Methods:
- Twelve male beagles underwent PAE with either bleomycin-eluting or bland HepaSphere microspheres.
- Prostate volume and ischemic volume were measured using magnetic resonance imaging.
- Histopathological examination of prostate and adjacent organs was performed post-procedure.
Main Results:
- PAE with bleomycin-eluting microspheres resulted in significantly greater prostate volume reduction at 1 and 3 months compared to bland microspheres.
- A larger proportion of prostate ischemic volume was observed in the bleomycin-eluting group at 1 month.
- No complications or non-target embolization were reported in either group.
Conclusions:
- PAE with bleomycin-eluting microspheres is a feasible and well-tolerated procedure in a canine model.
- This technique effectively induces ischemic necrosis and reduces prostate volume in BPH.
- Bleomycin-eluting microspheres show promise as an enhanced therapeutic agent for PAE in BPH treatment.
