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The effect of PLGA molecular weight differences on risperidone release from microspheres.

Moe Kohno1, Janki V Andhariya1, Bo Wan1

  • 1University of Connecticut, School of Pharmacy, Storrs, CT 06269, United States.

International Journal of Pharmaceutics
|April 20, 2020
PubMed
Summary

Poly (lactic-co-glycolic acid) molecular weight did not impact risperidone microsphere release. Instead, drug release depended on polymer glass transition temperature and porosity, due to risperidone

Keywords:
In vitro releaseMicrospheresPoly(lactic-co-glycolic acid) (PLGA)PorosityRisperidoneUSP apparatus 4

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Area of Science:

  • Pharmaceutical Sciences
  • Polymer Chemistry
  • Drug Delivery

Background:

  • Poly (lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer for drug delivery systems.
  • Controlling the in vitro release profile of drugs from PLGA microspheres is crucial for therapeutic efficacy.

Purpose of the Study:

  • To investigate the influence of different poly (lactic-co-glycolic acid) molecular weights on the in vitro release of risperidone from microspheres.
  • To elucidate the factors governing risperidone release from PLGA microspheres.

Main Methods:

  • Preparation of risperidone microspheres using four different molecular weights of PLGA via a consistent manufacturing process.
  • Characterization of microsphere physicochemical properties, including particle size, drug loading, morphology, and molecular weight.
  • Evaluation of in vitro degradation profiles and in vitro drug release using a flow-through cell apparatus (USP apparatus 4).

Main Results:

  • Microsphere particle size varied, but drug loading remained consistent across formulations.
  • In vitro drug release profiles were independent of the PLGA molecular weight.
  • Drug release was primarily influenced by the glass transition temperature and porosity of the PLGA polymers.

Conclusions:

  • The molecular weight of PLGA did not significantly affect the in vitro release of risperidone from microspheres.
  • Risperidone's catalytic effect on PLGA degradation during manufacturing and release testing minimized molecular weight-dependent differences.
  • Glass transition temperature and microsphere porosity are key determinants of risperidone release from PLGA systems.