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Late onset hyperplastic callus formation in osteogenesis imperfecta type V simulating osteosarcoma-A case report
Hans Christoph Vonderlind1, Matthias Jessel1, Alexander Knobel1
1Department of Orthopaedics and Traumatology, University Hospital Oldenburg, Germany.
International Journal of Surgery Case Reports
|April 20, 2020
Summary
Late onset hyperplastic callus formation (HPC) in osteogenesis imperfecta (OI) type V can mimic osteosarcoma. Early recognition of HPC in OI type V is crucial to prevent misdiagnosis and ensure appropriate patient management.
Area of Science:
- Orthopedics
- Genetics
- Radiology
Background:
- Osteogenesis imperfecta (OI) type V presents with diverse clinical and radiographic features.
- Hyperplastic callus formation (HPC) is a rare complication of OI type V.
Observation:
- A 27-year-old female with type V OI presented with a 2-3 month history of right femur swelling.
- Initial radiographic findings suggested osteosarcoma, with elevated bone metabolism markers.
- Advanced imaging (CT, MRI) and biopsy confirmed late-onset HPC.
Findings:
- The case highlights late-onset hyperplastic callus formation in type V osteogenesis imperfecta.
- Radiographic and clinical presentation mimicked malignant osteosarcoma.
- Differential diagnoses for such presentations include osteosarcoma, periostitis, myositis ossificans, and osteomyelitis.
Implications:
- Accurate diagnosis of HPC in OI type V is essential to avoid misdiagnosis as osteosarcoma.
- Advanced imaging modalities such as CT, MRI, and scintigraphy are recommended for diagnosis.
- Understanding rare complications like HPC improves management strategies for patients with osteogenesis imperfecta.
Keywords:
Hyperplastic callus formationOsteogenesis imperfecta type VRadiographySimulation of osteosarcomaMore Related Videos
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