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Hepatotoxicity due to Atractylis gummifera-L
M Georgiou1, L Sianidou, T Hatzis
1Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, Greece.
Journal of Toxicology. Clinical Toxicology
|January 1, 1988
Summary
A child suffered fatal poisoning from Atractylis gummifera root extract, a traditional medicine. The case highlights severe liver and kidney damage, emphasizing the dangers of unregulated herbal remedies.
Area of Science:
- Toxicology
- Herbal Medicine
- Pediatrics
Background:
- Atractylis gummifera, a plant used in traditional medicine, contains toxic compounds.
- Accidental or intentional ingestion of toxic plants can lead to severe health consequences, particularly in children.
Observation:
- A 7-year-old boy ingested Atractylis gummifera root extract for medicinal purposes.
- He presented with coma, epigastric pain, vomiting, and anxiety 2 days post-ingestion.
Findings:
- Laboratory results revealed severe hepatocellular damage and acute renal failure.
- Postmortem histopathology confirmed panlobular hepatic necrosis, indicative of severe liver injury.
Implications:
- This case underscores the critical need for caution and regulation regarding the use of traditional herbal medicines.
- It highlights the potential for severe toxicity, including liver and kidney failure, from Atractylis gummifera.
- Accurate diagnosis and prompt medical intervention are crucial for managing plant-induced poisonings.