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[Association between GPX1 gene polymorphisms and noise-induced hearing loss]
1National Center for Occupational Safety and health, NHC, Beijing 102308, China.
Summary
Genetic variations in the Glutathione peroxidase 1 gene (GPX1) are linked to increased risk of noise-induced hearing loss (NIHL). Specific GPX1 polymorphisms may identify individuals susceptible to hearing damage from occupational noise exposure.
Area of Science:
- Genetics
- Occupational Health
- Audiology
Background:
- Noise-induced hearing loss (NIHL) is a significant occupational health concern.
- Genetic factors are increasingly recognized as contributing to individual susceptibility to NIHL.
- The Glutathione peroxidase 1 (GPX1) gene plays a role in cellular antioxidant defense, potentially influencing protection against noise damage.
Purpose of the Study:
- To investigate the association between genetic polymorphisms in the GPX1 gene and the risk of developing NIHL.
- To identify specific GPX1 single nucleotide polymorphisms (SNPs) that may confer susceptibility to noise-induced hearing damage.
Main Methods:
- A nested case-control study was conducted on noise-exposed steel factory workers.
- 392 cases of NIHL were matched with 392 controls based on gender, age, and noise exposure duration.
- Two GPX1 SNPs (rs1987628) were genotyped, and their association with NIHL was analyzed using logistic regression.
Main Results:
- Both genotyped SNPs were in Hardy-Weinberg equilibrium.
- The rs1987628 polymorphism showed a statistically significant association with NIHL risk under codominant and dominant models.
- Individuals with the rs1987628 GA genotype had a higher NIHL risk (aOR=1.803), as did those with GA+AA genotypes (aOR=1.762).
Conclusions:
- Genetic polymorphism in the GPX1 gene is suggested to be a potential genetic susceptibility factor for NIHL.
- The rs1987628 SNP in GPX1 may increase an individual's risk of developing hearing loss due to noise exposure.
- These findings highlight the role of genetic predisposition in occupational NIHL.
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