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Novel 2019 coronavirus: Genome structure, clinical trials, and outstanding questions

Manasi P Jogalekar1, Anurag Veerabathini2, Prakash Gangadaran3,4

  • 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Experimental Biology and Medicine (Maywood, N.J.)
|April 21, 2020
PubMed
Abstract

Insights

Understanding the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for developing effective vaccines and treatments during the COVID-19 pandemic. This research explores alternative strategies to accelerate therapeutic development and mitigate the global health crisis.

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, necessitates rapid development of vaccines and treatments.
  • Conventional vaccine development timelines are insufficient for the current public health emergency.
  • Understanding viral pathophysiology is key to identifying effective countermeasures.

Purpose of the Study:

  • To highlight the importance of understanding SARS-CoV-2 pathophysiology.
  • To explore alternative strategies for vaccine and therapeutic development.
  • To provide insights that could accelerate the response to the COVID-19 pandemic.

Main Methods:

  • Literature review on SARS-CoV-2 pathophysiology.
  • Analysis of current vaccine development challenges.
  • Exploration of novel therapeutic approaches.

Main Results:

  • Early SARS-CoV-2 genetic sequence availability has spurred vaccine research.
  • Pathophysiological insights are crucial for targeted interventions.
  • Alternative strategies may expedite the availability of life-saving medical countermeasures.

Conclusions:

  • Accelerated understanding of SARS-CoV-2 is vital for public health.
  • Innovative approaches are needed to overcome traditional vaccine development timelines.
  • This work aims to provide critical insights for combating the COVID-19 pandemic.
Keywords:
2019-nCoVCOVID-19ChinaMERS-CoVSARS-CoVSARS-CoV-2Wuhancoronavirus

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