Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The first two decades of vitamin E.

K E Mason

    Federation Proceedings
    |May 1, 1977
    PubMed
    Summary

    Vitamin E, identified in 1925, was crucial for reproduction. Early research uncovered multiple deficiency symptoms and led to the isolation and synthesis of alpha-tocopherol.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Changing Concepts of the Antisterility Vitamin (Vitamin E).

    The Yale journal of biology and medicine·2011
    Same author

    Pigmentation of the Sex Glands in Vitamin E Deficient Rats.

    The Yale journal of biology and medicine·2011
    Same author

    Highly unsaturated fatty acids and pigmentation of adipose tussue in vitamin E deficient rats.

    The Anatomical record·2010
    Same author

    Dental changes of rats and hamsters in vitamin E deficiency.

    Journal of dental research·2010
    Same author

    Histological changes in adipose tissue of rats fed a vitamin E deficient diet high in cod liver oil.

    The Anatomical record·2010
    Same author

    Vitamin E deficiency in the monkey.

    The Anatomical record·2010

    Area of Science:

    • Biochemistry
    • Nutritional Science
    • Endocrinology

    Background:

    • The discovery of vitamin E stemmed from identifying a critical antisterility factor in rats.
    • This factor was integrated into the vitamin family in 1925, marking the beginning of extensive research.

    Observation:

    • Deficiency studies revealed diverse health issues including embryonic mortality, reproductive organ degeneration, and neurological/muscular disorders in various species.
    • Key milestones included the isolation of vitamin E and the naming of its primary form, alpha-tocopherol, in 1936.

    Findings:

    • The structural formula of alpha-tocopherol was determined, enabling its chemical synthesis and commercial production from plant oils.
    • The existence of other, less active tocopherols was identified, broadening the understanding of vitamin E's chemical nature.

    Implications:

    • The development of a chemical assay for vitamin E significantly advanced research by replacing cumbersome bioassays.
    • These advancements facilitated a deeper understanding of vitamin E's distribution and biological functions in foods, tissues, and fluids.

    Related Experiment Videos