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Related Concept Videos

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Insula functional connectivity in schizophrenia.

Julia M Sheffield1, Baxter P Rogers2, Jennifer Urbano Blackford3

  • 1Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, TN, USA.

Schizophrenia Research
|April 21, 2020
PubMed
Summary
This summary is machine-generated.

Schizophrenia alters insula connectivity, impacting cognitive and affective processing. This study reveals distinct sub-region connectivity changes linked to cognitive function and negative symptoms in patients.

Keywords:
CognitionInsulaNegative symptomsPositive symptomsResting-state functional connectivitySchizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • The insula shows structural abnormalities in schizophrenia across illness stages.
  • Functional connectivity of insula sub-regions is less understood, particularly in schizophrenia.
  • Distinct insula sub-regions (dorsal anterior, ventral anterior, posterior) have specialized functions.

Purpose of the Study:

  • To characterize resting-state functional connectivity sub-region profiles of the insula in schizophrenia.
  • To investigate associations between insula sub-region connectivity and clinical symptoms.
  • To explore functional dysconnectivity patterns in schizophrenia.

Main Methods:

  • Resting-state functional connectivity analysis in a large cohort of schizophrenia (N=191) and healthy (N=196) participants.
  • Characterization of connectivity profiles for dorsal anterior insula (dAI), ventral anterior insula (vAI), and posterior insula (PI).
  • Correlation analysis between insula sub-region connectivity and clinical/cognitive measures.

Main Results:

  • Schizophrenia exhibits altered insula sub-region connectivity, with reduced within-network and increased aberrant external connectivity.
  • Connectivity profiles of dAI and PI showed increased similarity, while dAI and vAI showed decreased similarity.
  • Reduced dAI connectivity correlated with cognitive deficits (r=0.18, p=0.014).
  • Increased vAI connectivity with the superior temporal sulcus correlated with negative symptoms (r=0.27, p<0.001).

Conclusions:

  • Insula sub-regions display altered functional connectivity in schizophrenia, supporting widespread functional dysconnectivity.
  • Aberrant connectivity in dAI and vAI is linked to specific cognitive and negative symptoms, respectively.
  • Findings suggest impaired insula sub-region differentiation contributes to schizophrenia pathophysiology.