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Updated: Dec 23, 2025
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Effect of the Hydoxyurea in Yemeni Transfusion-Dependent β-Thalassemia Patients
Hafiz A Al-Nood1, Rasha M Al-Nood2, Najeeb S Ghanem2
1Department of Hematology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Abstract:
The response to hydroxyurea (HU) therapy of 44 Yemeni transfusion-dependent β-thalassemia (β-thal) patients in Sana'a City, Yemen, was assessed. All patients were treated with a dose of 15 mg/kg/day HU for 4-10 months. Thirty-six patients responded partially to HU with clinical improvement of anemia and extramedullary hematopoiesis features, whereas the rest remained almost at the same baseline levels of transfusion dependency. Hydroxyurea was shown to have a variable favorable effect on β-thal in Yemeni patients. Further study is required to identify the various response factors to HU therapy, as well as to investigate its long-term efficacy and safety.
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