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Update on canine filaggrin: a review
Daniel Combarros1,2, Marie-Christine Cadiergues1,2, Michel Simon1
1UDEAR, Université de Toulouse, INSERM UPS, Toulouse, France.
The Veterinary Quarterly
|April 21, 2020
Summary
Canine filaggrin (Flg) shares similarities with human filaggrin (FLG) in skin barrier function, but its role in canine atopic dermatitis (CAD) remains unclear due to conflicting research and limited genetic data.
Area of Science:
- Veterinary Dermatology
- Molecular Biology
- Genetics
Background:
- Human filaggrin (FLG) is crucial for skin barrier function; mutations cause atopic dermatitis (AD).
- FLG expression decreases in human AD due to Th2 cytokines.
- Canine atopic dermatitis (CAD) closely resembles human AD clinically and pathogenically.
Purpose of the Study:
- To review current knowledge on canine filaggrin (Flg) in healthy and atopic dogs.
- To compare canine Flg with human FLG.
Main Methods:
- Comparison of canine and human filaggrin gene sequences.
- Review of existing literature on Flg expression in canine atopic dermatitis.
Main Results:
- Canine and human filaggrin share similar epidermal expression sites and processing.
- Canine and human profilaggrin (proFLG) sequences show low overall similarity (33%), but higher N-terminal similarity (75%).
- Conflicting results exist for Flg mRNA levels in CAD; protein-level data is scarce.
Conclusions:
- Despite structural differences, canine and human filaggrin have functional similarities.
- The role of Flg in canine atopic dermatitis pathogenesis requires further investigation.
- Limited genetic studies and breed diversity pose challenges for CAD research.
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