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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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[Neurodevelopment and cannabis].

M-O Krebs1, F Demars1, A Frajerman1

  • 1Pôle hospitalo-universitaire évaluation, prévention et innovation thérapeutique, centre d'évaluation pour jeunes adultes et adolescents (CJAAD), GHU psychiatrie et neurosciences, site Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.

Bulletin De L'Academie Nationale De Medecine
|April 21, 2020
PubMed
Summary
This summary is machine-generated.

Exposure to delta-9-tetrahydrocannabinol during critical brain development periods, from prenatal stages through adolescence, can disrupt neurodevelopment. This early cannabis exposure may lead to lasting cognitive, psychotic, and addictive issues.

Keywords:
AdolescenceBrain maturationCognitionPsychosisTetrahydrocannabinol

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pharmacology

Context:

  • Brain development involves critical plasticity periods sensitive to environmental influences.
  • The endocannabinoid system plays a key role in brain maturation and plasticity.
  • Delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, impacts this system.

Purpose:

  • To review the effects of cannabis exposure on neurodevelopment.
  • To highlight the risks associated with prenatal, perinatal, and adolescent exposure.
  • To emphasize the role of cannabinoid receptors in these disruptions.

Summary:

  • Cannabis exposure during fetal development, perinatal stages, and adolescence disrupts ordered brain maturation.
  • Delta-9-tetrahydrocannabinol interacts with the endocannabinoid system, particularly cannabinoid receptor 1 (CB1R), leading to abnormal neurodevelopment.
  • This disruption can result in persistent cognitive, psychotic, and addictive disturbances.

Impact:

  • Early cannabis exposure poses a significant risk factor for long-term neurodevelopmental complications.
  • Animal models and human studies confirm the detrimental effects of exposure during critical developmental phases.
  • Disseminating objective information is crucial for preventing early exposure and mitigating consequences.