Related Experiment Video

Updated: Dec 23, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.1K

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer

Márcia Fernanda Correia Jardim Paz1,2, Marcus Vinícius Oliveira Barros de Alencar3, Rodrigo Maciel Paulino de Lima3

  • 1Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil.

Oxidative Medicine and Cellular Longevity
|April 21, 2020
PubMed

Insights

Long-term omeprazole (OME) use may increase gastric cancer risk by inducing genomic instability. While OME has protective effects, potential adverse effects like genotoxicity warrant caution.

Area of Science:

  • Pharmacology
  • Genetics
  • Gastroenterology

Background:

  • Omeprazole (OME) is a widely prescribed medication for gastrointestinal disorders.
  • Long-term OME use has been linked to an increased risk of gastric cancer.
  • Understanding OME's pharmacological effects and toxicogenetic risks is crucial.

Purpose of the Study:

  • To characterize the pharmacological effects of omeprazole.
  • To correlate OME's adverse effects and toxicogenetic risks with genomic instability mechanisms.
  • To evaluate OME's association with cancer based on existing database reports.

Main Methods:

  • Comprehensive literature search conducted on PubMed, Scopus, and ScienceDirect up to August 2019.
  • Inclusion of 80 clinical reports, 46 in vitro studies, and 76 in vivo studies.
  • Analysis of pharmacological data, adverse effects, and toxicogenetic profiles.

Main Results:

  • Findings suggest long-term omeprazole use (5-40 mg/kg) may induce genomic instability, though results are debated.
  • OME exhibits protective effects via proton pump blockade, anti-inflammatory activity, and increased gastric flow.
  • Adverse effects include atrophic gastritis, cobalamin deficiencies, polyp development, hepatotoxicity, cytotoxicity, and genotoxicity.

Conclusions:

  • Omeprazole may induce genomic instability, potentially increasing the risk of certain cancers.
  • OME-mediated protective mechanisms involve anti-inflammatory and antiapoptotic pathways.
  • Adequate precautions are necessary for long-term omeprazole therapy and self-medication practices.

More Related Videos

Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays04:07

Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays

Published on: February 24, 2023

2.1K
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.4K

Related Concept Videos

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.8K
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.6K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.0K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.2K
Effects of Chemicals: Overview01:27

Effects of Chemicals: Overview

Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.9K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.5K