Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

287
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
287
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

41.4K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bi-analyte demonstration of non-resonant, single-molecule SERS with isolated lithographic enhancement structures.

Scientific reports·2026
Same author

Design of isolated lithographic SERS structures with enhanced sensitivity.

Scientific reports·2025
Same author

Idiopathic central sleep apnea: the past, the present, and the future.

Sleep·2025
Same author

Nocturnal Oxygen Therapy for Central Sleep Apnea in Patients with Heart Failure: A Multisite, Double-Blind, Sham-controlled Randomized Clinical Trial (LOFT-HF).

Annals of the American Thoracic Society·2025
Same author

Outcomes Following Metoidioplasty and Phalloplasty Gender Affirming Surgery With Urethral Lengthening: A Modified Delphi Consensus Study.

Urology·2025
Same author

Catecholamine exposure and the gut microbiota in obstructive sleep apnea.

PeerJ·2025

Related Experiment Video

Updated: Dec 23, 2025

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

8.9K

Smart Lighting Clinical Testbed Pilot Study on Circadian Phase Advancement.

Joseph D Gleason1, Meeko Oishi1, Michelle Simkulet2

  • 11Electrical and Computer EngineeringUniversity of New MexicoAlbuquerqueNM87131USA.

IEEE Journal of Translational Engineering in Health and Medicine
|April 21, 2020
PubMed
Summary

This study tested a new hospital-based lighting system designed to regulate human biological clocks. By adjusting light color and brightness in patient rooms, researchers successfully shifted the sleep-wake cycles of participants, proving that such technology can be used for future health research.

Keywords:
Lighting controlbiomedical engineeringcircadian rhythmsystem implementationchronobiologyhospital lightingmelatonin onsettranslational research

Frequently Asked Questions

More Related Videos

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.5K
Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity
00:08

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

1.5K

Related Experiment Videos

Last Updated: Dec 23, 2025

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

8.9K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.5K
Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity
00:08

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

1.5K

Area of Science:

  • Chronobiology research within smart lighting clinical testbed systems
  • Translational medicine and environmental health science

Background:

No prior work had resolved how to effectively integrate tunable illumination systems into active hospital wards for long-term monitoring. That uncertainty drove the need for a dedicated infrastructure capable of supporting complex biological rhythm investigations. Prior research has shown that light exposure serves as a primary driver for internal body clocks. However, most existing evidence relies on artificial laboratory settings that do not reflect real-world patient experiences. This gap motivated the development of a specialized environment for testing circadian regulation in clinical settings. Researchers have long understood that light intensity and spectral composition influence human health outcomes. Yet, translating these findings into hospital care remains a significant challenge for modern medicine. The current project addresses these limitations by establishing a functional testbed for continuous physiological observation.

Purpose Of The Study:

The objective of this work is to construct a clinical inpatient testbed utilizing advanced illumination technology. Researchers aimed to evaluate the feasibility of this system for future large-scale medical studies. The project addresses the challenge of conducting chronobiological research in environments that do not overly constrain human subjects. By establishing a feedback-capable infrastructure, the team sought to demonstrate that variable spectrum lighting can be deployed in active hospital wards. This effort was motivated by the need to translate laboratory findings into practical clinical applications. The authors intended to prove that continuous sensing and lighting control are achievable in a real-world setting. Furthermore, the study aimed to confirm that subject recruitment and retention are viable for multi-day, round-the-clock investigations. The researchers established this testbed to provide a foundation for future inquiries into the health impacts of environmental light.

Main Methods:

The team designed a specialized inpatient facility equipped with feedback-capable, variable spectrum illumination hardware. Review approach involved installing overhead troffers integrated with advanced color and occupancy sensing modules. Computing infrastructure facilitated continuous communication between the light sources and data collection software. Investigators executed a five-day protocol to assess the reliability of the system in an active hospital ward. Subject recruitment and retention strategies were tested to ensure feasibility for long-term clinical monitoring. The approach prioritized minimizing patient constraints while maintaining precise control over environmental light parameters. Researchers collected salivary samples to track biological markers throughout the duration of the trial. This methodology focused on validating the proof of principle for future large-scale chronobiological studies.

Main Results:

The primary finding demonstrates that the installed system successfully induced phase advancement in all three study participants. Key findings from the literature suggest that the hardware and software functioned without interruption during the five-day observation period. The researchers confirmed that the troffer-based lighting effectively varied both intensity and spectral content as intended. Data gathered from salivary samples provided clear evidence of shifts in the internal body clocks of the subjects. The study successfully validated that continuous sensing is possible within a busy clinical environment. Recruitment and retention metrics indicated that multi-day, round-the-clock protocols are feasible for this patient population. The team observed that their lighting approach did not overly restrict the movement of the participants. These results collectively support the viability of the testbed for future translational research in hospital settings.

Conclusions:

The authors suggest that their hospital-based infrastructure successfully supports complex chronobiological investigations. This pilot project demonstrates that variable spectrum illumination can be deployed within active patient care environments. The findings indicate that participants can be recruited and retained for multi-day, continuous monitoring protocols. The researchers propose that their troffer-based system effectively achieves circadian phase shifts in human subjects. This work highlights the potential for translating laboratory-based lighting research into practical clinical applications. The team notes that their approach minimizes constraints on patients compared to traditional light box methods. The study provides a foundation for future inquiries into the health impacts of controlled environmental light. These results confirm the feasibility of using smart lighting to influence biological rhythms in hospital settings.

The researchers observed phase advancement in all three participants by adjusting the timing, intensity, and spectral output of the overhead troffers. This shift was confirmed through the analysis of salivary dim-light melatonin onset samples collected during the five-day trial.

The infrastructure integrates variable spectrum troffers with specialized color and occupancy sensors. These hardware components connect to a central computing and communication network to ensure seamless data acquisition and light regulation throughout the clinical trial period.

A clinical setting was necessary to evaluate whether the technology could operate reliably in an active hospital ward. This environment allowed the team to test subject retention and system performance under real-world conditions that traditional laboratory light boxes cannot replicate.

The system utilizes both color and occupancy sensors to provide real-time feedback. These tools allow the software to adjust lighting parameters dynamically while simultaneously gathering biometric data from the subjects throughout the duration of the study.

The team measured dim-light melatonin onset using salivary samples. This specific biomarker serves as a reliable indicator of the internal circadian phase, allowing the investigators to track shifts in the subjects' biological rhythms over the five-day period.

The authors propose that their approach enables more realistic experiments that do not overly restrict patient movement. They suggest this flexibility is vital for translating lighting research into standard hospital practice and expanding future investigations into environmental health impacts.