Urethral carcinoma: A compilation of case studies and research findings

There are three major recognized histological types for primary urethral carcinoma (PUC). These include transitional cell carcinoma (55%), squamous cell carcinoma (21.5%), and adenocarcinoma (16.4%). However, primary urethral carcinoma still only accounts for approximately less than 1% of all bladder cancers. Current management includes surgery alone or surgery with adjunctive radiotherapy and chemotherapy. Current research suggests that in those cases managed with only surgery, the five-year disease-free survival is only 20-30%; as additional treatment with radiotherapy and chemotherapy is new recommendation, there is no published statistical data to suggest outcomes, only current clinical observation.