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Updated: Dec 23, 2025

Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head
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Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head

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Insulinoma Identified in Puerperium: Association with Pregnancy and Literature Review

Rossana Orabona1,2, Cristina Zanardini2, Andrea Lojacono1,2

  • 1Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

European Journal of Case Reports in Internal Medicine
|April 21, 2020
PubMed

Postpartum hypoglycemia in non-diabetic women is a rare condition. We report the case of a 34-year-old woman who experienced neuroglycopenia 2 days after delivery. Corresponding to severe hypoglycemia, we found inappropriately elevated insulin and C-peptide levels. Following magnetic resonance imaging a lesion of 10×8 mm was detected in the head of the pancreas. An ultrasound-guided fine needle aspiration of the mass confirmed the diagnostic suspicion of a pancreatic neuroendocrine tumor. Complete surgical enucleation of the insulinoma resulted in immediate and permanent resolution of the hypoglycemia. The postoperative course was uneventful. Histopathological and immunohistochemical analyses were consistent with insulinoma. The diagnostic approach to postpartum hypoglycemia represents a challenge for multidisciplinary teamwork.

Keywords:
Neuroendocrine tumorhypoglycemiainsulinomaneuroglycopeniapostpartumpregnancypuerperium

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