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Association between lipoprotein(a) concentration and the risk of stroke in the Chinese Han population: a

Hanhui Fu1, Dingding Zhang2, Rui Zhu3

  • 1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

Annals of Translational Medicine
|April 21, 2020
PubMed

Insights

Elevated Lipoprotein(a) [Lp(a)] levels are linked to increased risk for both ischemic and hemorrhagic strokes. This association is particularly strong in men and younger individuals within the Chinese Han population.

Area of Science:

  • Cardiovascular Science
  • Neurology
  • Biochemistry

Background:

  • Lipoprotein(a) [Lp(a)] is a known risk factor for coronary heart disease.
  • The association between Lp(a) levels and stroke risk, particularly different stroke subtypes, remains less defined.
  • Understanding Lp(a)'s role in stroke is crucial for risk stratification and prevention strategies.

Purpose of the Study:

  • To investigate the association between serum Lipoprotein(a) [Lp(a)] concentrations and the risk of ischemic and hemorrhagic stroke.
  • To evaluate potential differences in this association based on stroke type, sex, and age.

Main Methods:

  • A single-center, retrospective case-control study involving 1,953 ischemic stroke patients, 196 hemorrhagic stroke patients, and matched healthy controls.
  • Lipoprotein(a) [Lp(a)] levels were measured using the latex agglutination turbidimetric method.
  • Conditional logistic regression models were employed to assess the association between Lp(a) quartiles and stroke risk, adjusting for relevant covariates.

Main Results:

  • Median Lp(a) levels were significantly higher in both ischemic and hemorrhagic stroke patients compared to controls.
  • Elevated Lp(a) showed a significant positive association with increased risk for both ischemic stroke (ORs ranging from 2.03 to 2.36) and hemorrhagic stroke (ORs ranging from 1.93 to 3.24) across higher quartiles.
  • Stratified analyses indicated a significant association between elevated Lp(a) and ischemic stroke risk in men, with a trend towards higher risk in younger patients.

Conclusions:

  • Elevated serum Lipoprotein(a) [Lp(a)] is a significant independent risk factor for both ischemic and hemorrhagic stroke in the Chinese Han population.
  • The risk associated with elevated Lp(a) is more pronounced in men and younger individuals.
  • These findings highlight Lp(a) as a potential biomarker for stroke risk assessment.
Abstract

Keywords:
Lipoprotein(a) [Lp(a)]case-control studyhemorrhagic strokeischemic stroke

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