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Updated: Dec 23, 2025
Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
Published on: August 9, 2019
Impact of maternal and neonatal factors on umbilical cord CD34+ cells
Mohamed A Rowisha1, Mohamed R El-Shanshory1, Eslam E El-Hawary1
1Pediatric Department, Faculty of Medicine, Tanta University Faculty of Medicine, Tanta University, Tanta, Egypt.
Background:
The achievement of optimal number of CD34+ umbilical cord stem cells is essential for successful umbilical cord stem cell transplantation. So the aim of this study was to assess the potential effect of both maternal and neonatal factors on the umbilical cord blood CD34+ cell count.
Methods:
The study was done on umbilical cord blood samples obtained from 20 mothers during labor. Their ages ranged from 22 to 34 years and were subjected to history taking, physical examination of the baby and assessment of the CD34+ cells count in umbilical cord blood.
Results:
Number of previous live births and weight of the baby had a significant effect on CD34+ cells count while the sex of the baby, delivery route, maternal age and gestation period had no significant effect on CD34+ cells count.
Conclusions:
Umbilical cord blood-derived CD34+ cell count is better with good weight and first babies and decreased with subsequent babies.
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