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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Hypertrophic cardiomyopathy

Murillo de Oliveira Antunes1,2, Thiago Luis Scudeler1

  • 1Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

International Journal of Cardiology. Heart & Vasculature
|April 21, 2020
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a common inherited heart condition with varied outcomes. This review covers clinical issues and treatment options for managing HCM symptoms and progression.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease.
  • HCM presents with diverse clinical manifestations, from asymptomatic cases to severe heart failure or sudden cardiac death.
  • Left ventricular hypertrophy and altered ventricular shape often lead to dynamic left ventricular outflow obstruction.

Purpose of the Study:

  • To review the key clinical issues associated with hypertrophic cardiomyopathy.
  • To summarize current pharmacological and therapeutic interventions for HCM.
  • To provide an overview of treatment strategies aimed at symptom alleviation and disease management.

Main Methods:

  • Literature review of clinical issues in hypertrophic cardiomyopathy.
  • Summary of current pharmacotherapies for HCM.
  • Overview of septal reduction therapies for HCM.

Main Results:

  • HCM is characterized by significant variability in presentation and progression.
  • Dynamic left ventricular outflow obstruction is common in HCM patients.
  • Pharmacological therapies and septal reduction therapies are primary treatment modalities.

Conclusions:

  • Effective management of HCM requires addressing its variable nature and potential complications.
  • Treatment goals focus on alleviating symptoms and improving the natural history of the disease.
  • A comprehensive understanding of clinical issues and treatment options is crucial for HCM patient care.

Keywords:
CMR, cardiac magnetic resonanceHCM, hypertrophic cardiomyopathyHF, heart failureISH, interventricular septal hypertrophyLVH, left ventricular hypertrophyLVOT, left ventricular outflow tractSAM, systolic anterior motionSCD, sudden cardiac death

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