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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Blood Typing01:10

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
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The ABO Blood Group01:12

The ABO Blood Group

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
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Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: Dec 23, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Blood Transfusion in the 21st Century.

Mark T Friedman1, Vaidehi Avadhani1, Sandra Gilmore2

  • 1Department of Pathology, Blood Bank and Transfusion Services.

Discoveries (Craiova, Romania)
|April 21, 2020
PubMed
Summary

Blood transfusion safety has improved, but new risks like bacterial contamination and immune system damage require better patient blood management strategies. This review covers innovations and best practices for safer blood use.

Keywords:
Blood substitutesfactor concentrateshemovigilancepatient blood managementtransfusion medicine educationtransfusion safety

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Blood supply safety significantly improved due to viral disease screening (HIV, hepatitis).
  • Emerging concerns include non-viral diseases (bacterial contamination, Chagas), prion agents, and transfusion-related acute lung injury (TRALI).
  • Inappropriate blood transfusions pose risks, including potential long-term immune system damage and increased patient mortality.

Purpose of the Study:

  • To review current blood safety challenges and risks.
  • To examine advancements in blood safety technology.
  • To highlight the importance of patient blood management strategies.

Main Methods:

  • Review of scientific literature on blood transfusion safety.
  • Analysis of emerging infectious and non-infectious transfusion risks.
  • Discussion of technological innovations in blood safety.

Main Results:

  • Despite advances, bacterial contamination and TRALI remain significant risks.
  • Patient blood management is crucial for optimizing transfusion outcomes.
  • New technologies are enhancing blood safety screening and component management.

Conclusions:

  • Continuous improvement in blood safety requires addressing both infectious and non-infectious risks.
  • Effective patient blood management strategies are essential to minimize transfusion-related harm.
  • Technological innovation plays a key role in ensuring a safe and appropriate blood supply.