Temperature and Salting out Effects on Nicotine Dissolution Kinetics in Saline Solutions

Area of Science:

• Physical Chemistry
• Chemical Engineering

Background:

• Understanding solute dissolution kinetics is crucial for various chemical processes.
• Nicotine's behavior in saline solutions is relevant to environmental and industrial contexts.

Purpose of the Study:

• To investigate the dissolution rate of nicotine in aqueous sodium chloride (NaCl) solutions.
• To determine the effect of NaCl concentration and temperature on nicotine dissolution and diffusion coefficients.

Main Methods:

• Quantitative visualization of microscopic nicotine droplet shrinkage.
• Application of the Epstein-Plesset mathematical model.
• Experiments conducted at room temperature and 70 °C with varying NaCl concentrations (15-26 wt %).

Main Results:

• Nicotine dissolution rate and diffusion coefficients decreased with increasing NaCl concentration at room temperature.
• At 70 °C, dissolution decreased with 15-20% NaCl but showed less temperature dependence at 25% NaCl.
• Dissolution was higher at 70 °C than room temperature for saturated (26%) NaCl solutions.

Conclusions:

• Sodium chloride concentration significantly influences nicotine dissolution kinetics and diffusion.
• Temperature effects on nicotine dissolution are concentration-dependent, particularly near saturation.
• The findings provide valuable data for modeling nicotine transport in saline environments.